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NeuroImage, Volume 39
Volume 39, Number 1, January 2008
- Jaymin Upadhyay, Kevin Hallock, Mathieu Ducros, Dae-Shik Kim, Itamar Ronen:
Diffusion tensor spectroscopy and imaging of the arcuate fasciculus. 1-9 - Bradford C. Dickerson, E. Fenstermacher, David H. Salat, David A. Wolk, Ralph Paul Maguire, Rahul Desikan, Jennifer L. Pacheco, Brian T. Quinn, André J. W. van der Kouwe, Douglas N. Greve, Deborah Blacker, Marilyn S. Albert, Ronald J. Killiany, Bruce Fischl:
Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengths. 10-18 - Peter Schlindwein, M. Mueller, Thomas Bauermann, Thomas Brandt, Peter Stoeter, Marianne Dieterich:
Cortical representation of saccular vestibular stimulation: VEMPs in fMRI. 19-31 - Jason P. Lerch, Jeffrey B. Carroll, Shoshana Spring, Lisa N. Bertram, Claudia Schwab, Michael R. Hayden, R. Mark Henkelman:
Automated deformation analysis in the YAC128 Huntington disease mouse model. 32-39 - Leeanne Carey, David F. Abbott, Gary F. Egan, Geoffrey Donnan:
Reproducible activation in BA2, 1 and 3b associated with texture discrimination in healthy volunteers over time. 40-51 - Antonio Giorgio, Kate E. Watkins, Gwenaëlle Douaud, A. C. James, S. James, Nicola De Stefano, Paul M. Matthews, Steve M. Smith, Heidi Johansen-Berg:
Changes in white matter microstructure during adolescence. 52-61 - I. Nigel C. Lawes, Thomas R. Barrick, Vengadasalam Murugam, Natalia Spierings, David R. Evans, Marie Song, Chris A. Clark:
Atlas-based segmentation of white matter tracts of the human brain using diffusion tensor tractography and comparison with classical dissection. 62-79
- Hans-Jürgen Huppertz, Jan Kassubek, Dirk-Matthias Altenmüller, T. Breyer, Susanne Fauser:
Automatic curvilinear reformatting of three-dimensional MRI data of the cerebral cortex. 80-86 - Antonino Mario Cassarà, Gisela E. Hagberg, Marta Bianciardi, Michele Migliore, Bruno Maraviglia:
Realistic simulations of neuronal activity: A contribution to the debate on direct detection of neuronal currents by MRI. 87-106 - Stefan K. Piechnik, Peter A. Chiarelli, Peter Jezzard:
Modelling vascular reactivity to investigate the basis of the relationship between cerebral blood volume and flow under CO2 manipulation. 107-118 - Philipp Stämpfli, Carolin Reischauer, T. Jaermann, Anton Valavanis, Spyros S. Kollias, Peter Boesiger:
Combining fMRI and DTI: A framework for exploring the limits of fMRI-guided DTI fiber tracking and for verifying DTI-based fiber tractography results. 119-126 - Grégory Operto, Rémy Bulot, Jean-Luc Anton, Olivier Coulon:
Projection of fMRI data onto the cortical surface using anatomically-informed convolution kernels. 127-135 - Anjum A. Sharief, Alexandra Badea, Anders M. Dale, G. Allan Johnson:
Automated segmentation of the actively stained mouse brain using multi-spectral MR microscopy. 136-145 - F. DuBois Bowman, Brian Caffo, Susan Spear Bassett, Clint Kilts:
A Bayesian hierarchical framework for spatial modeling of fMRI data. 146-156 - Alard Roebroeck, Ralf Galuske, Elia Formisano, Oriana Chiry, Hansjürgen Bratzke, Itamar Ronen, Dae-Shik Kim, Rainer Goebel:
High-resolution diffusion tensor imaging and tractography of the human optic chiasm at 9.4 T. 157-168 - Jarkko Ylipaavalniemi, Ricardo Vigário:
Analyzing consistency of independent components: An fMRI illustration. 169-180 - Karl J. Friston, Carlton Chu, Janaina Mourão Miranda, Oliver J. Hulme, Geraint Rees, Will D. Penny, John Ashburner:
Bayesian decoding of brain images. 181-205 - Moriah E. Thomason, Gary H. Glover:
Controlled inspiration depth reduces variance in breath-holding-induced BOLD signal. 206-214 - Jeffrey I. Berman, SungWon Chung, Pratik Mukherjee, Christopher Paul Hess, Eric T. Han, Roland G. Henry:
Probabilistic streamline q-ball tractography using the residual bootstrap. 215-222 - Xin Yu, Jing Zou, James S. Babb, Glyn Johnson, Dan H. Sanes, Daniel H. Turnbull:
Statistical mapping of sound-evoked activity in the mouse auditory midbrain using Mn-enhanced MRI. 223-230 - Scott A. Kruse, Gregory H. Rose, Kevin J. Glaser, Armando Manduca, Joel P. Felmlee, Clifford R. Jack Jr., Richard L. Ehman:
Magnetic resonance elastography of the brain. 231-237 - Stephanie Powell, Vincent Magnotta, Hans J. Johnson, Vamsi K. Jammalamadaka, Ronald Pierson, Nancy Andreasen:
Registration and machine learning-based automated segmentation of subcortical and cerebellar brain structures. 238-247 - Fuqiang Zhao, Tiejun Zhao, Lei Zhou, Qiu-Lin Wu, Xiaoping Hu:
BOLD study of stimulation-induced neural activity and resting-state connectivity in medetomidine-sedated rat. 248-260 - Jeanette A. Mumford, Thomas E. Nichols:
Power calculation for group fMRI studies accounting for arbitrary design and temporal autocorrelation. 261-268 - André C. Marreiros, Stefan J. Kiebel, Karl J. Friston:
Dynamic causal modelling for fMRI: A two-state model. 269-278 - Raymond Salvador, Angel Martinez-Perez, Edith Pomarol-Clotet, Jesús J. Gomar, Fidel Vila, Salvador Sarró, Antoni Capdevila, Edward T. Bullmore:
A simple view of the brain through a frequency-specific functional connectivity measure. 279-289 - Roberto C. Sotero, Nelson J. Trujillo-Barreto:
Biophysical model for integrating neuronal activity, EEG, fMRI and metabolism. 290-309 - Robert H. Kraus Jr., Petr L. Volegov, Andrei N. Matlachov, Michelle A. Espy:
Toward direct neural current imaging by resonant mechanisms at ultra-low field. 310-317 - Nelson J. Trujillo-Barreto, Eduardo Aubert-Vázquez, William D. Penny:
Bayesian M/EEG source reconstruction with spatio-temporal priors. 318-335 - Kegang Hua, Jiangyang Zhang, Setsu Wakana, Hangyi Jiang, Xin Li, Daniel S. Reich, Peter A. Calabresi, James J. Pekar, Peter C. M. van Zijl, Susumu Mori:
Tract probability maps in stereotaxic spaces: Analyses of white matter anatomy and tract-specific quantification. 336-347 - Paul Aljabar, Kanwal K. Bhatia, Maria Murgasova, Joseph V. Hajnal, James P. Boardman, Latha Srinivasan, Mary A. Rutherford, Leigh Dyet, A. David Edwards, Daniel Rueckert:
Assessment of brain growth in early childhood using deformation-based morphometry. 348-358 - Anthonin Reilhac, Sandrine Tomeï, Irène Buvat, Christian Michel, Frank Keheren, Nicolas Costes:
Simulation-based evaluation of OSEM iterative reconstruction methods in dynamic brain PET studies. 359-368
- Lorenzo Bello, Anna Gambini, Antonella Castellano, Giorgio Carrabba, Francesco Acerbi, Enrica Fava, Carlo Giussani, Marcello Cadioli, Valeria Blasi, Alessandra Casarotti, Costanza Papagno, Arun Kumar Gupta, Sergio Gaini, Giuseppe Scotti, Andrea Falini:
Motor and language DTI Fiber Tracking combined with intraoperative subcortical mapping for surgical removal of gliomas. 369-382 - Sabina Hotz-Boendermaker, Marion Funk, Paul E. Summers, Peter C. Brugger, Marie-Claude Hepp-Reymond, Armin Curt, Spyros Sreejanth Kollias:
Preservation of motor programs in paraplegics as demonstrated by attempted and imagined foot movements. 383-394
- Lesya Y. Ganushchak, Niels O. Schiller:
Motivation and semantic context affect brain error-monitoring activity: An event-related brain potentials study. 395-405 - Jeffrey D. Johnson, Brian Minton, Michael D. Rugg:
Content dependence of the electrophysiological correlates of recollection. 406-416 - Stephanie Rotzer, Karin Kucian, Ernst Martin, Michael von Aster, Peter Klaver, Thomas Loenneker:
Optimized voxel-based morphometry in children with developmental dyscalculia. 417-422 - Lynne E. Bernstein, Edward T. Auer Jr., Michael Wagner, Curtis W. Ponton:
Spatiotemporal dynamics of audiovisual speech processing. 423-435 - Brian T. Miller, Timothy D. Verstynen, Marcia K. Johnson, Mark D'Esposito:
Prefrontal and parietal contributions to refreshing: An rTMS study. 436-440 - Jenna L. Riis, Hyemi Chong, Katherine K. Ryan, David A. Wolk, Dorene M. Rentz, Phillip J. Holcomb, Kirk R. Daffner:
Compensatory neural activity distinguishes different patterns of normal cognitive aging. 441-454 - Riju Srimal, Clayton E. Curtis:
Persistent neural activity during the maintenance of spatial position in working memory. 455-468 - Ray Johnson Jr., Heather Henkell, Elizabeth Simon, John Zhu:
The self in conflict: The role of executive processes during truthful and deceptive responses about attitudes. 469-482 - Takamitsu Watanabe, Sho Yagishita, Hideyuki Kikyo:
Memory of music: Roles of right hippocampus and left inferior frontal gyrus. 483-491 - Florian Koppelstaetter, Thorsten D. Poeppel, Christian M. Siedentopf, Anja Ischebeck, Michael Verius, Ilka A. Haala, Felix M. Mottaghy, Paul Rhomberg, Stefan Golaszewski, Thaddaeus Gotwald, Ingo H. Lorenz, Christian Kolbitsch, Stephan Felber, Bernd J. Krause:
Does caffeine modulate verbal working memory processes? An fMRI study. 492-499 - Hideki Ohira, Tokiko Isowa, Michio Nomura, Naho Ichikawa, Kenta Kimura, Makoto Miyakoshi, Tetsuya Iidaka, Seisuke Fukuyama, Toshihiko Nakajima, Jitsuhiro Yamada:
Imaging brain and immune association accompanying cognitive appraisal of an acute stressor. 500-514 - Anja Soldan, Eric Zarahn, H. John Hilton, Yaakov Stern:
Global familiarity of visual stimuli affects repetition-related neural plasticity but not repetition priming. 515-526 - Clare Kelly, Lucina Q. Uddin, Bharat B. Biswal, F. Xavier Castellanos, Michael P. Milham:
Competition between functional brain networks mediates behavioral variability. 527-537 - Jeffrey C. Cooper, Brian Knutson:
Valence and salience contribute to nucleus accumbens activation. 538-547
- Jason L. Stein, Lisa M. Wiedholz, Danielle S. Bassett, Daniel R. Weinberger, Caroline F. Zink, Venkata S. Mattay, Andreas Meyer-Lindenberg:
Corrigendum to "A validated network of effective amygdala connectivity" [NeuroImage 36 (2007) 736-745]. 548
Volume 39, Number 2, January 2008
- Juha Silvanto, Neil G. Muggleton:
New light through old windows: Moving beyond the "virtual lesion" approach to transcranial magnetic stimulation. 549-552 - Stefan J. Borgwardt, Philip K. McGuire, Paolo Fusar-Poli, Ernst-Wilhelm Radue, Anita Riecher-Rössler:
Anterior cingulate pathology in the prodromal stage of schizophrenia. 553-554
- Hiroshi Ito, Hidehiko Takahashi, Ryosuke Arakawa, Harumasa Takano, Tetsuya Suhara:
Normal database of dopaminergic neurotransmission system in human brain measured by positron emission tomography. 555-565 - Jung-Lung Hsu, Alexander Leemans, Chyi-Huey Bai, Cheng-Hui Lee, Yuh-Feng Tsai, Hou-Chang Chiu, Wei-Hung Chen:
Gender differences and age-related white matter changes of the human brain: A diffusion tensor imaging study. 566-577 - Carolina Ciumas, Per Lindström, Bernard Aoun, Ivanka Savic:
Imaging of odor perception delineates functional disintegration of the limbic circuits in mesial temporal lobe epilepsy. 578-592 - Kiyoshi Egawa, Naoko Asahina, Hideaki Shiraishi, Kyousuke Kamada, Fumiya Takeuchi, Shingo Nakane, Akira Sudo, Shinobu Kohsaka, Shinji Saitoh:
Aberrant somatosensory-evoked responses imply GABAergic dysfunction in Angelman syndrome. 593-599 - Mitsuo Suzuki, Ichiro Miyai, Takeshi Ono, Kisou Kubota:
Activities in the frontal cortex and gait performance are modulated by preparation. An fNIRS study. 600-607 - Khalid Hamandi, Helmut Laufs, Ulrike Nöth, David W. Carmichael, John S. Duncan, Louis Lemieux:
BOLD and perfusion changes during epileptic generalised spike wave activity. 608-618 - Alexander Drzezga, Timo Grimmer, Gjermund Henriksen, Isabelle Stangier, Robert Perneczky, Janine Diehl-Schmid, Chester A. Mathis, William E. Klunk, Julie C. Price, Steven DeKosky, Hans-Jürgen Wester, Markus Schwaiger, Alexander Kurz:
Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease. 619-633
- Ingo Schießl, Wei Wang, Niall McLoughlin:
Independent components of the haemodynamic response in intrinsic optical imaging. 634-646 - Serge O. Dumoulin, Brian A. Wandell:
Population receptive field estimates in human visual cortex. 647-660 - Adrian G. Guggisberg, Heidi E. Kirsch, Mary M. Mantle, Nicholas M. Barbaro, Srikantan S. Nagarajan:
Fast oscillations associated with interictal spikes localize the epileptogenic zone in patients with partial epilepsy. 661-668 - Jian Yang, Ed X. Wu:
Detection of cortical gray matter lesion in the late phase of mild hypoxic-ischemic injury by manganese-enhanced MRI. 669-679 - Jonathan C. W. Brooks, Christian F. Beckmann, Karla L. Miller, Richard G. Wise, Carlo A. Porro, Irene Tracey, Mark Jenkinson:
Physiological noise modelling for spinal functional magnetic resonance imaging studies. 680-692 - Uri Hasson, Jeremy I. Skipper, Michael Wilde, Howard C. Nusbaum, Steven L. Small:
Improving the analysis, storage and sharing of neuroimaging data using relational databases and distributed computing. 693-706 - Robert Becker, Petra Ritter, Arno Villringer:
Influence of ongoing alpha rhythm on the visual evoked potential. 707-716 - Alane S. Kimes, Svetlana I. Chefer, John A. Matochik, Carlo Contoreggi, D. Bruce Vaupel, Elliot A. Stein, Alexey G. Mukhin:
Quantification of nicotinic acetylcholine receptors in the human brain with PET: Bolus plus infusion administration of 2-[18F]F-A85380. 717-727 - Stefan J. Kiebel, Jean Daunizeau, Christophe Phillips, Karl J. Friston:
Variational Bayesian inversion of the equivalent current dipole model in EEG/MEG. 728-741 - Yusuke Takeda, Kentaro Yamanaka, Yoshiharu Yamamoto:
Temporal decomposition of EEG during a simple reaction time task into stimulus- and response-locked components. 742-754 - Christophe Grova, Jean Daunizeau, Eliane Kobayashi, Andrew P. Bagshaw, Jean-Marc Lina, François Dubeau, Jean Gotman:
Concordance between distributed EEG source localization and simultaneous EEG-fMRI studies of epileptic spikes. 755-774 - Joanna K. Huttunen, Olli Gröhn, Markku Penttonen:
Coupling between simultaneously recorded BOLD response and neuronal activity in the rat somatosensory cortex. 775-785
- Klaus Jahn, Angela Deutschländer, Thomas Stephan, Roger Kalla, Martin Wiesmann, Michael Strupp, Thomas Brandt:
Imaging human supraspinal locomotor centers in brainstem and cerebellum. 786-792 - Matthew R. G. Brown, Tutis Vilis, Stefan Everling:
Isolation of saccade inhibition processes: Rapid event-related fMRI of saccades and nogo trials. 793-804 - Daniel Richard Leff, Clare E. Elwell, Felipe Orihuela-Espina, Louis Atallah, David T. Delpy, Ara Darzi, Guang-Zhong Yang:
Changes in prefrontal cortical behaviour depend upon familiarity on a bimanual co-ordination task: An fNIRS study. 805-813 - Petroc Sumner, Elaine Anderson, Richard Sylvester, John-Dylan Haynes, Geraint Rees:
Combined orientation and colour information in human V1 for both L-M and S-cone chromatic axes. 814-824 - Man Cheuk Ng, Ed X. Wu, Ho-Fai Lau, Yong Hu, Edmund Y. Lam, Keith Dip-Kei Luk:
Cervical spinal cord BOLD fMRI study: Modulation of functional activation by dexterity of dominant and non-dominant hands. 825-831 - Christopher J. Machado, Abraham Z. Snyder, Simon R. Cherry, Pierre Lavenex, David G. Amaral:
Effects of neonatal amygdala or hippocampus lesions on resting brain metabolism in the macaque monkey: A microPET imaging study. 832-846
- Micah M. Murray, Christian Camen, Lucas Spierer, Stephanie Clarke:
Plasticity in representations of environmental sounds revealed by electrical neuroimaging. 847-856 - Karin Schon, Sule Tinaz, David Somers, Chantal E. Stern:
Delayed match to object or place: An event-related fMRI study of short-term stimulus maintenance and the role of stimulus pre-exposure. 857-872 - Sinéad M. Rhodes, David I. Donaldson:
Electrophysiological evidence for the effect of interactive imagery on episodic memory: Encouraging familiarity for non-unitized stimuli during associative recognition. 873-884 - Sarah Wiethoff, Dirk Wildgruber, Benjamin Kreifelts, Hubertus Becker, Cornelia Herbert, Wolfgang Grodd, Thomas Ethofer:
Cerebral processing of emotional prosody - influence of acoustic parameters and arousal. 885-893 - Paul Wright, Dolores Albarracin, Rick D. Brown, Hong Li, Guojun He, Yijun Liu:
Dissociated responses in the amygdala and orbitofrontal cortex to bottom-up and top-down components of emotional evaluation. 894-902 - Berna Güroglu, Gerbert J. T. Haselager, Cornelis F. M. van Lieshout, Atsuko Takashima, Mark Rijpkema, Guillén Fernández:
Why are friends special? Implementing a social interaction simulation task to probe the neural correlates of friendship. 903-910
- Hideki Mochizuki, Norihiro Sadato, Daisuke N. Saito, Hiroshi Toyoda, Manabu Tashiro, Nobuyuki Okamura, Kazuhiko Yanai:
Erratum to "Neural correlates of perceptual difference between itching and pain: A human fMRI study" [NeuroImage 36 (2007) 706-717]. 911-912 - David E. Rex, David W. Shattuck, Roger P. Woods, Katherine L. Narr, Eileen Luders, Kelly Rehm, Sarah E. Stoltzner, David A. Rottenberg, Arthur W. Toga:
Erratum to "A meta-algorithm for brain extraction in MRI" [NeuroImage 23 (2004) 625-637]. 913 - Pierre Jannin, Xavier Morandi:
Erratum to "Surgical models for computer-assisted neurosurgery" [NeuroImage 37 (2007) 783-791]. 914
Volume 39, Number 3, February 2008
- Donna J. Cross, Jennifer A. Flexman, Yoshimi Anzai, Kenneth Maravilla, Satoshi Minoshima:
Age-related decrease in axonal transport measured by MR imaging in vivo. 915-926 - Arnaud Cachia, Marie-Laure Paillère-Martinot, André Galinowski, Dominique Januel, Renaud de Beaurepaire, Frank Bellivier, Eric Artiges, Jamila Andoh, David Bartrés-Faz, Edouard Duchesnay, Denis Rivière, Marion Plaze, Jean-François Mangin, Jean-Luc Martinot:
Cortical folding abnormalities in schizophrenia patients with resistant auditory hallucinations. 927-935 - Frederic Lauwers, Francis Cassot, Valerie Lauwers-Cances, Prasanna Puwanarajah, Henri Duvernoy:
Morphometry of the human cerebral cortex microcirculation: General characteristics and space-related profiles. 936-948 - Gary Price, Mara Cercignani, Geoffrey J. M. Parker, Daniel R. Altmann, Thomas R. E. Barnes, Gareth J. Barker, Eileen M. Joyce, Maria A. Ron:
White matter tracts in first-episode psychosis: A DTI tractography study of the uncinate fasciculus. 949-955 - Janey Prodoehl, Hong Yu, Deborah M. Little, Ivy Abraham, David E. Vaillancourt:
Region of interest template for the human basal ganglia: Comparing EPI and standardized space approaches. 956-965 - Andreas Ströhle, Meline Stoy, Jana Wrase, Steffi Schwarzer, Florian Schlagenhauf, Michael Huss, Jakob Hein, Anke Nedderhut, Britta Neumann, Andreas Gregor, Georg Juckel, Brian Knutson, Ulrike Lehmkuhl, Michael Bauer, Andreas Heinz:
Reward anticipation and outcomes in adult males with attention-deficit/hyperactivity disorder. 966-972 - Ze Wang, María A. Fernández-Seara, David C. Alsop, Wen-Ching Liu, Judy Flax, April A. Benasich, John A. Detre:
Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI. 973-978 - Bruno-Marcel Mackert, Stefanie Leistner, Tilmann Heinrich Sander, Adam Liebert, Heidrun Wabnitz, Martin Burghoff, Lutz Trahms, Rainer Macdonald, Gabriel Curio:
Dynamics of cortical neurovascular coupling analyzed by simultaneous DC-magnetoencephalography and time-resolved near-infrared spectroscopy. 979-986 - Frithjof Kruggel, Joseph Suresh Paul, Hermann Josef Gertz:
Texture-based segmentation of diffuse lesions of the brain's white matter. 987-996 - Hiroshi Toyoda, Kenichi Kashikura, Tomohisa Okada, Satoru Nakashita, Manabu Honda, Yoshiharu Yonekura, Hideo Kawaguchi, Atsushi Maki, Norihiro Sadato:
Source of nonlinearity of the BOLD response revealed by simultaneous fMRI and NIRS. 997-1013 - Junghoon Kim, Brian B. Avants, Sunil Patel, John Whyte, H. Branch Coslett, John Pluta, John A. Detre, James C. Gee:
Structural consequences of diffuse traumatic brain injury: A large deformation tensor-based morphometry study. 1014-1026 - Walter Maetzler, Matthias Reimold, Inga Liepelt, Christoph Solbach, Thomas Leyhe, Katherine Schweitzer, Gerhard W. Eschweiler, Michel Mittelbronn, Alexandra Gaenslen, Michael Uebele, Gerald Reischl, Thomas Gasser, Hans-Jürgen Machulla, Roland Bares, Daniela Berg:
[11C]PIB binding in Parkinson's disease dementia. 1027-1033 - Jennifer L. Whitwell, Clifford R. Jack Jr., V. Shane Pankratz, Joseph E. Parisi, David S. Knopman, Bradley F. Boeve, Ronald C. Petersen, Dennis W. Dickson, Keith A. Josephs:
Rates of brain atrophy over time in autopsy-proven frontotemporal dementia and Alzheimer disease. 1034-1040 - Jurgen E. M. Mourik, Mark Lubberink, Ursula M. H. Klumpers, Emile F. I. Comans, Adriaan A. Lammertsma, Ronald Boellaard:
Partial volume corrected image derived input functions for dynamic PET brain studies: Methodology and validation for [11C]flumazenil. 1041-1050
- Dik Kin Wong, Logan Grosenick, E. Timothy Uy, Marcos Perreau Guimaraes, Claudio Carvalhaes, Peter Desain, Patrick Suppes:
Quantifying inter-subject agreement in brain-imaging analyses. 1051-1063 - David W. Shattuck, Mubeena Mirza, Vitria Adisetiyo, Cornelius Hojatkashani, Georges Salamon, Katherine L. Narr, Russell A. Poldrack, Robert M. Bilder, Arthur W. Toga:
Construction of a 3D probabilistic atlas of human cortical structures. 1064-1080 - Jozien B. M. Goense, Shih-Pi Ku, Hellmut Merkle,